Di: Lorenzo

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HARAKEH S, JARIWALLA R., PAULING L,.”Suppression of human immunodeficiency virus replication by
ascorbate in chronically and acutely infected cells”, Proc. Nati. Acad. Sci., Vol. 87, pp. 7245-7249, 1990
The concentrations at which the anti-HIV effect of ascorbate
was seen in this in vitro study are physiologically
attainable in human blood plasma. For instance, in a clinical
trial on terminal cancer patients, E. Cameron (personal
communication) showed that oral administration of 10 g of
ascorbate resulted in mean plasma ascorbate levels of 28.91 mcg/ml (range 17.2-63.6 g).
B. Jaffe (personal communication),who is using ascorbate for the treatment of AIDS patients, indicated that ascorbate at 93 mcg/ml was attained in plasma in people consuming oral ascorbate to
achieve urinary levels >1 mg/ml. AIDS patients have extremely high bowel tolerance for oral ascorbate. Intravenous infusion of 50 g of ascorbate a day resulted in peak plasma levels of 796 mcg/ml.
Prolonged ascorbate treatment of HIV in the presence of VB cells resulted in a drop in retroviral activity of a factor of 3-14 with ascorbate at 100 and 150 pAg/ml.
Under similar conditions, in cells that were expressing HIV at peak levels, ascorbate reduced the levels of
extracellular reverse transcriptase activity by 99% and that of p24 antigen by 90% in the culture supernatant.
Oxidative stress seems to have an important influence on the degree of positivity of the tests used. However, the underlining molecular mechanisms are not fully understood.